Veronica Human was last seen in Lentegeur, Mitchells Plain on Monday April 1.
The 16-year-old was wearing a white t-shirt, blue skirt, pink slippers and a white scarf.
In another incident, Shandray Schoeman also disappeared in Lentegeur on the same day.
It is unknown what she was wearing at the time.
If you have any information about these two cases, contact Sergeant Nkenke on 063 363 7671 or the Pink Ladies on 072 214 7439.